Mothers and Newborns affected by Opioids (MNO) Initiative

Mothers and Newborns affected by Opioids Initiative (MNO)

Maternal opioid use has increased dramatically across the country in recent years with serious implications not only for mothers and infants. Neonatal Abstinence Syndrome (NAS) is a drug withdrawal syndrome in newborns, resulting from sudden discontinuation of exposure to opioids after birth and is associated with low birthweight. The severity and onset of NAS varies, but the symptoms can include mild tremors irritability, fever, excessive weight loss, and seizures.1 The NAS rate in Illinois in 2015 was 2.5 cases per 1,000 live births. Since 2011, the NAS rate in Illinois has increase by 42%.

The IPLQC Mothers and Newborns affected by Opiods (MNO) Initiative aims to work with the Illinois Department of Public Health NAS Advisory Committee to reduce the adverse outcomes of opioid use for mothers and babies by implementing best practices for identification and treatment opioid misuse for mothers and NAS for infants.

We currently have an interdisciplinary team of 47 members consisting of neonatologists, maternal fetal medicine specialists, OBGYNS, nurses, and a patient family advisor.


  1. Patrick, S. W., Davis, M. M., Lehman, C. U., & Cooper, W. O. (2015). Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009-2012. Journal of perinatology: official journal of the California Perinatal Association, 35(8), 650.

MNO Workgroup Call Slidesets:

June 2017

July 2017

September 2017

October 2017

November 2017

January 2018 MNO Wave 1 Team Launch Call

NAS Resources

Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes



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